Objectives : Through the study on Byeokyeoksinbang(辟疫神方), it would be expected to analyze Dokyeok(毒疫)’s characteristic and to comprehend how the changes in viewpoints of epidemic febrile disease were made. Methods : It has been done to analyze the original text of Byeokyeoksinbang(辟疫神方), and to compare the theory of Onbyeongjobyeon(溫病條辨) associated with the signature symptom of Dokyeok(毒疫). Results : Heo Jun(許浚) experienced a specific epidemic disease called ‘Dokyeok(毒疫)’, on which he made observations and analyzed its features and wrote Byeokyeoksinbang(辟疫神方). In Byeokyeoksinbang(辟疫神方), ‘Dokyeok(毒疫)’ is characterized by rash[疹], its pathogenesis is warm temperature, thus its treatment principle is removing interior and exterior heat. The book's pragmatic perspective is highly appreciated, as HeoJun improved and solidified existing medical knowledge up to date. In addition, Byeokyeoksinbang(辟疫神方) is significant in that it differentiated between macula[癍疹] and rash[疹], much earlier than the febrile disease school of the Qing dynasty. Conclusions : Between Byeokyeoksinbang(辟疫神方) and Onbyeongjobyeon(溫病條辨), there are differences in treatments and patterns of rash[疹]. Based on this, it will be able to compare each disease that is written in two books. And a study on comparing the development between epidemic febrile disease[瘟疫學] of the Joseon dynasty and febrile disease[溫病學] of the Qing dynasty will be carried out with a follow-up study.